European journal of medicinal chemistry

Synthesis and evaluation of hexahydropyrrolo [3, 4-d] isoxazole-4, 6-diones as anti-stress agents

R Badru, P Anand, B Singh

文献索引：Badru, Rahul; Anand, Preet; Singh, Baldev European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 81 - 91

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被引用次数: 13

摘要

A series of 2, 3-diphenyl-5-(naphthalen-1-yl)-4H-2, 3, 3a, 5, 6, 6a-hexahydropyrrolo [3, 4-d] isoxazole-4, 6-dione derivatives were synthesized via 1, 3-dipolar cycloaddition of azomethine N-oxides with N-(α-naphthyl) maleimide. The pyrrolo-isoxazole derivatives were assigned cis-and trans-configurations (3-A and 3-B) with respect to proton C3-H on azomethinic carbon on the basis of their 1H NMR. The reaction proceeds through cis- ...