Design, synthesis and antimalarial activity of benzene and isoquinoline sulfonamide derivatives

MK Parai, G Panda, K Srivastava, SK Puri

文献索引：Kumar Parai, Maloy; Panda, Gautam; Srivastava, Kumkum; Kumar Puri, Sunil Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 776 - 781

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被引用次数: 31

摘要

A new series of benzene and isoquinoline sulfonamide derivatives were synthesized by nucleophilic displacement reaction on benzene and isoquinoline sulfonyl chlorides by substituted amines (primary and secondary). The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2–50μg/mL.