9-(2-aryloxyethyl) derivatives of adenine-a new class of non-nucleosidic antiviral agents

…, C Pannecouque, J Balzarini, E De Clercq

文献索引：Petrov; Ozerov; Novikov; Pannecouque; Balzarini; De Clercq Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 9 p. 1218 - 1226

全文：HTML全文

被引用次数: 14

摘要

Abstract New 9-(aryloxyalkyl) derivatives of adenine have been prepared by alkylation of adenine with tosylates, bromides, and α-chloro ethers containing terminal aromatic fragments in anhydrous DMF in the presence of potassium carbonate. The compounds of the 9-(2-phenoxyethyl) adenine series appear to be highly reactive against cytomegaloviruses of mankind in vitro, while derivatives of 9-(2-benzyloxyethyl) adenine ...