Synthesis of (E)-9-(Propen-1-yl)-9 H-adenine, a Mutagenic Impurity in Tenofovir Disoproxil Fumarate

…, NR Mutyala, SR Chennupati

文献索引：Chavakula, Ramadas; Mutyala, Narayanarao; Chennupati, Srinivasarao Organic Preparations and Procedures International, 2013 , vol. 45, # 4 p. 336 - 340

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被引用次数: 1

摘要

Tenofovir disoproxil fumarate is a highly potent antiviral agent, particularly for the therapy or prophylaxis of retroviral infections and belongs to a class of drugs called Nucleoside Reverse Transcriptase Inhibitors (NRTI) which blocks reverse transcriptase, an enzyme crucial for the production of the virus in HIV-infected patients. 1–6 Several impurities are generated during manufacture of tenofovir disoproxil fumarate from adenine. The US ...