Tetrahedron

Practical one-pot preparation of ketones from aryl and alkyl bromides with aldehydes and DIH via Grignard reagents

S Dohi, K Moriyama, H Togo

文献索引：Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2012 , vol. 68, # 32 p. 6557 - 6564

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被引用次数: 12

摘要

Various diaryl ketones, alkyl aryl ketones, and dialkyl ketones were efficiently prepared in good yields by the reactions of the Grignard reagents derived from aryl or alkyl bromides, followed by the reactions with aromatic or aliphatic aldehydes and the subsequent treatment with 1, 3-diiodo-5, 5-dimethylhydantoin and K2CO3, in a one-pot method. The same treatment of aromatic bromides bearing electron-withdrawing groups, such as ester, nitrile, ...