DABCO-mediated synthesis and biological activity of cyanohydrin esters.

HMR Hoffmann, ZM Ismail, R Hollweg…

文献索引：Hoffmann, H. M. R.; Ismail, Z. M.; Hollweg, Reiner; Zein, Abdul R. Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 6 p. 1807 - 1810

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被引用次数: 40

摘要

1808 as efficient latent acyl anions in the preparation of ketones and in 1,4-addition reactions,4»5' ie as Michael donors. Hitherto they have been synthesized by several routes“) Recently, Chenevert et al.8) have prepared cyanohydrin esters using solid-liquid phase transfer (PTC) conditions and an excess of cyanide ion. Due to the presence of 18-crown-6 the nucleo- philicity and solubility of cyanide ion in dichlorome- thane is dramatically ...