Chemistry Letters

A Direct Synthesis of γ-, δ-, and ε-Lactones Utilizing SmI 2-induced Barbier-type Reaction in the Presence of Hexamethylphosphoric Triamide (HMPA)

K Otsubo, K Kawamura, J Inanaga, M Yamaguchi

文献索引：Otsubo, Kenji; Kawamura, Kisa; Inanaga, Junji; Yamaguchi, Masaru Chemistry Letters, 1987 , p. 1487 - 1490

全文：HTML全文

被引用次数: 57

摘要

By using an efficient reduction system of SmI 2-THF-HMPA, the coupling reaction of β-, γ, or δ-bromoesters with carbonyl compounds was completed within a minute at room temperature affording γ-, δ-, or ε-lactones, respectively, in good yields. Cp 2 ZrCl 2 was also found to be effective for the coupling with ketones.