Journal of medicinal chemistry

Comparative toxicities and analgesic activities of three monomethylated analogs of acetaminophen

PJ Harvison, AJ Forte, SD Nelson

文献索引：Harvison, Peter J.; Forte, Anthony J.; Nelson, Sidney D. Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1737 - 1743

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被引用次数: 31

摘要

Three monomethylated derivatives of 4'-hydroxyacetanilide (acetaminophen) were prepared in order to compare their cytotoxic potential and analgesic activity with that of acetaminophen. Only 4 '-hydroxy-N-methylacetanilide (N-methylacetaminophen) was devoid of cytotoxic effects to hepatic tissue of mice. Results of comparative tissue distribution studies and metabolism studies both in vivo and in vitro in mice indicate that the ...