Synthesis of β-Dimethylaminoethyl and α-Hydroxy-β-Dimethylaminoethyl Derivatives from Organolithium Compounds and Tetramethyoxamide

E Campaigne, G Skowronski…

文献索引：Campaigne,E. et al. Synthetic Communications, 1973 , vol. 3, p. 325 - 332

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被引用次数: 17

摘要

Abstract The important biological activity of a variety of aromatic and heterocyclic systems having β-dimethylaminoethyl side chains and their α-hydroxy analogs (cf bufotenin, N- methylepinephrine, etc.) has focused the attention of the organic chemist on methods of introducing these functions, and a variety of approaches have been developed. A convenient synthesis has recently been reported3, which utilizes the α-hydroxy-β- ...