Harnessing Functional Plasticity of Enzymes: A Fluorogenic Probe for Imaging 17β-HSD10 Dehydrogenase, an Enzyme Involved in Alzheimer's and Parkinson's …
MK Froemming, D Sames
文献索引：Froemming, Mary K.; Sames, Dalibor Journal of the American Chemical Society, 2007 , vol. 129, # 46 p. 14518 - 14522
In this paper, we describe the development of a fluorogenic substrate for 17β- hydroxysteroiddehydrogenase type 10 (17β-HSD10), which is a multifunctional metabolic enzyme fulfilling several metabolic roles (β-oxidation of fatty acids, catabolism of isoleucine, and metabolism of steroids). In recent years, it has emerged as an important stress and pathological marker in neurons and glial cells (expression down-regulation in Parkinson's ...
