Investigation into the structure–activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists

WF McCalmont, JR Patterson, MA Lindenmuth…

文献索引：McCalmont, William F.; Patterson, Jaclyn R.; Lindenmuth, Michael A.; Heady, Tiffany N.; Haverstick, Doris M.; Gray, Lloyd S.; Macdonald, Timothy L. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 11 p. 3821 - 3839

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被引用次数: 36

摘要

This paper describes the synthesis and biological evaluation of a series of straight chain analogs of a compound (1) that was previously synthesized in our research program. These compounds, which are T-type calcium channel antagonists, exhibits potent anti-proliferative activity against a variety of cancer cells. A structure–activity relationship of these analogs against a variety of cancer cells has provided insight into a logical pharmacophore for this ...