Scientia Pharmaceutica 2011-03-01

New substituted isocoumarins and Dihydroisocoumarins and their cytotoxic activities.

Veronika Hampl, Isolde Wetzel, Franz Bracher, Jürgen Krauss

文献索引：Sci. Pharm. 79(1) , 21-30, (2011)

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摘要

New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).