Bioorganic & Medicinal Chemistry Letters 2008-01-01

Structure–activity relationship studies of the chromosome segregation inhibitor, Incentrom A

Hee-Yoon Lee, Yongsik Jung, Wonyeob Kim, Jin Hee Kim, Min-Soo Suh, Seung Koo Shin, Hye-Joo Yoon, Hee-Yoon Lee, Yongsik Jung, Wonyeob Kim, Jin Hee Kim, Min-Soo Suh, Seung Koo Shin, Hye-Joo Yoon

文献索引：Bioorg. Med. Chem. Lett. 18(16) , 4670-4, (2008)

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摘要

Pharmacophore and structure–activity relationship of Incentrom A that inhibits the chromosome segregation process in yeast were established. A series of Incentrom A analogs were synthesized and tested for the anti-yeast activity.