Journal of the American Chemical Society

Rhodium-catalyzed methylenation of aldehydes

H Lebel, V Paquet

文献索引：Lebel, Helene; Paquet, Valerie Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 320 - 328

全文：HTML全文

被引用次数: 79

摘要

The rhodium-catalyzed methylenation of aldehydes using trimethylsilyldiazomethane and triphenylphosphine produces a variety of terminal alkenes in excellent yields. These mild and nonbasic reaction conditions allow the conversion of enolizable substrates (keto aldehydes and nonracemic α-substituted aldehydes) to terminal alkenes without epimerization. Optimization of the reaction conditions led to the conclusion that a variety of ...