Bioorganic & Medicinal Chemistry Letters 2006-06-01

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.

Jin Hee Ahn, Seung Jun Kim, Woul Seong Park, Sung Yun Cho, Jae Du Ha, Sung Soo Kim, Seung Kyu Kang, Dae Gwin Jeong, Suk-Kyeong Jung, Sang-Hyeup Lee, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Seong Eon Ryu, Joong-Kwon Choi

文献索引：Bioorg. Med. Chem. Lett. 16 , 2996-2999, (2006)

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摘要

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.