A New Synthesis of Cyclohexenones: The Double Michael Addition of Vinyl Ethynyl Ketones to Active Methylene Compounds. Application to the Total Synthesis of dl- …
G Stork, M Tomasz
文献索引：Stork,G.; Tomasz,M. Journal of the American Chemical Society, 1964 , vol. 86, p. 471 - 478
The important orally active antifungal antibiotic griseofulvin (I) has established itself in medicine over the last f&;;. pers. 2 Originally isolated from penicillium griseofulvum, the antibiotic was eventually shown to have the structure4 and stereochemistry6 indicated in I. This stereochemistry has now been confirmed by X-ray analysk6
