Tetrahedron

Improved preparative route toward 3-arylcyclopropenes

WM Sherrill, R Kim, M Rubin

文献索引：Sherrill, William M.; Kim, Ryan; Rubin, Michael Tetrahedron, 2008 , vol. 64, # 37 p. 8610 - 8617

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被引用次数: 26

摘要

A convenient preparative protocol for the synthesis of various 3-arylcyclopropenes in a multigram scale is disclosed. Optimization of the reaction conditions and isolation procedures allowed for significant improvement of the chemical yields of these strained products. The described protocol was used for efficient preparation of a series of 3-methyl-3- arylcyclopropenes possessing different substituents in the aromatic ring. The effect of ...