Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol

…, PS Kumar, V Kuete, GN Folefoc, EA Nkengfack…

文献索引：Eyong, Kenneth O.; Kumar, Ponminor S.; Kuete, Victor; Folefoc, Gabriel N.; Nkengfack, Ephriam A.; Baskaran, Sundarababu Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5387 - 5390

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被引用次数: 56

摘要

Ozonolysis of lapachol (1), resulting in an unusual formation of a potent antitumor agent 2- acetylfuranonaphthoquinone (3) along with the expected aldehyde 6, is described. The reaction of lapachol (1) with CAN in dry acetonitrile leading to biologically active furanonaphthoquinones is also reported. The antitumoral activity of the tested compounds on human DU-145 prostate carcinoma cells was evaluated following XTT assay. The ...