Synthesis of some stable 7-halo-1, 4-thiazepines. Potential substituted penam precursors

P Blondeau, RGC Berse…

文献索引：Blondeau,P. et al. Canadian Journal of Chemistry, 1971 , vol. 49, p. 3866 - 3876

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被引用次数: 24

摘要

The synthesis of some new 3-carbomethoxy-5-oxoperhydro-1, 4-thiazepines is described. Halogenation studies led to the preparation of three potential substituted penam ring precursors: 6, 7-dibromo-3-carbomethoxy-5-oxoperhydro-1, 4-thiazepine, 3-carbomethoxy- 6, 7-dichloro-5-oxoperhydro-1, 4-thiazepine, and 3-carbomethoxy-7-chloro-6, 6-dimethyl-5- oxoperhydro-1, 4-thiazepine. Preliminary studies on the reactivity of these α- ...