Organic Letters 2002-08-08

Stereodivergent synthesis of enantiopure cis- and trans-3-Ethyl-4-piperidineacetates.

Mercedes Amat, Maria Pérez, Núria Llor, Joan Bosch

文献索引：Org. Lett. 4(16) , 2787-90, (2002)

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摘要

[reaction: see text] Starting from a common chiral bicyclic lactam 11, enantiopure trans- or cis-3-ethyl-4-piperidineacetate derivatives are obtained by conjugate addition of an enolate or a cuprate to the unsaturated lactams 12 or 18, respectively.