Journal of Heterocyclic Chemistry 2011-01-01

Synthesis of Novel Functionalized 4-Aza-2,3-Didehydropodophyllotoxin Derivatives with Potential Antitumor Activity.

Ajay Kumar, AntonioE Alegria

文献索引：J. Heterocycl. Chem. 47(6) , 1275-1282, (2010)

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摘要

Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.