Science 1980-11-07

Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog.

R M Freidinger, D F Veber, D S Perlow, J R Brooks, R Saperstein

文献索引：Science 210 , 656, (1980)

摘要

An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.

结构式	名称/CAS号	分子式	全部文献
	N-Fmoc-Freidinger′s lactam CAS:957507-85-6	C₂₄H₂₆N₂O₅

J.A. Robl et al.
[J. Am. Chem. Soc. 116 , 2348, (1994)]

Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog.

摘要

相关化合物