Synthesis study on marmycin A: preparation of the C3′-desmethyl analogues

C Ding, S Tu, F Li, Y Wang, Q Yao, W Hu…

文献索引：Ding, Chunyong; Tu, Shanghui; Li, Fuying; Wang, Yuanxiang; Yao, Qizheng; Hu, Wenxiang; Xie, Hua; Meng, Linghua; Zhang, Ao Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6111 - 6119

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被引用次数: 20

摘要

Total synthesis of natural product marmycin A was studied. An expeditious synthetic strategy for the key fragment 8-amino-3-methylbenz [a] anthraquinone (1) was established with decarboxylative alkylation, Pd (OAc) 2-catalyzed cyclization, aromatization, and C− N coupling as the key steps. However, final assembly of marmycin A was hampered by the failure to obtain the carbohydrate fragment 2. Instead, a small library of desmethyl ...