Potential Anticancer Agents--L. Non-Classical Antimetabolites--II. Some Factors in the Design of Exo-Alkylating Enzyme Inhibitors, partcularly of Lactic …

BR Baker, WW Lee, WA Skinner…

文献索引：Baker,B.R. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1960 , vol. 2, # 6 p. 633 - 657

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被引用次数: 51

摘要

Among the earliest known biochemical differences between normal and neoplastic tissues were the lowered oxygen uptake and high lactate formation of some neoplastic tissues compared to most normal tissues. l The enzymatic shunt of pyruvate to lactate with resultant regeneration of DPNt from DPNH is probably necessary for oxidative anabolism in an oxygen-deficient cell. Since this function of LDH is probably unessential for most, if not all, ...