Benzoylation of dianions: preparation of monobenzoylated derivatives of symmetrical secondary diamines

T Wang, Z Zhang, NA Meanwell

文献索引：Wang, Tao; Zhang, Zhongxing; Meanwell, Nicholas A. Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7661 - 7662

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被引用次数: 49

摘要

Monoacylated symmetrical secondary diamines are building blocks1 or intermediates2 widely used in the drug discovery process that are present in several investigational and established drugs. 3 Examples include the cardiotonic agent vesnarinone and the antihypertensive agent prazosin (Chart 1). Direct monoacylation of symmetrical diamines is frequently fraught with the complication associated with the tendency for bis-acylation to ...