Chemical & Pharmaceutical Bulletin 2005-02-01

Acaricidal daphnane diterpenoids from Trigonostemon reidioides (KURZ) CRAIB roots.

Noppamas Soonthornchareonnon, Monnun Sakayarojkul, Masahiko Isaka, Vanna Mahakittikun, Wongsatit Chuakul, Prapai Wongsinkongman

文献索引：Chem. Pharm. Bull. 53(2) , 241-3, (2005)

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摘要

A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of rediocide C (3) on the basis of spectral analysis. Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 microg/cm2.