Solution-phase microwave assisted parallel synthesis of N, N′-disubstituted thioureas derived from benzoic acid: Biological evaluation and molecular docking …

…, S Zaib, K Shoaib, M Shahid, U Floerke, J Iqbal

文献索引：Rauf, Muhammad Khawar; Talib, Ammara; Badshah, Amin; Zaib, Sumera; Shoaib, Khurram; Shahid, Mohammad; Floerke, Ulrich; Imtiaz-Ud-Din; Iqbal, Jamshed European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 487 - 496

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被引用次数: 13

摘要

Abstract An efficient and facile microwave-assisted solution phase parallel synthesis for a 26- member library of N, N′-disubstituted thiourea analogs were accomplished successfully. The reaction time for synthesis of analogs was drastically reduced from a reported 8–12 h to only 10 min. Compounds were more than 95% pure, as characterized by modern analytical techniques, ie 1 H & 13 C NMR and FT-IR. The solid phase structural analysis has also ...

~85%

~93%

~77%

~96%

Antiinflammatory Activity of New Aryl-and Aroylthioureas

[Baltabaev; Makhsumov; Zakirov; Babaev; Shukurullaev Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 2 p. 77 - 79]