Oxidation products of phenolic thiocolchicines: ring A quinones and dienones

J Guan, A Brossi, XK Zhu, HK Wang…

文献索引：Guan, Jian; Brossi, Arnold; Zhu, Xiao-Kang; Wang, Hui-Kang; Lee, Kuo-Hsiung Synthetic Communications, 1998 , vol. 28, # 9 p. 1585 - 1591

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被引用次数: 5

摘要

Jian Gum, Arnold Brossi', Xiao-Kang Zhu, Hui-Kang Wang and Kuo-Hsiung Lee' ... Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 ... Abstract: An improved, highly selective demethylation of thiocolchicine (1) to the dipheno15 is described. Oxidation of 2 to para-quinone 6 and of 4 and 5 to ortho-quinones 8 and 10 is first reported. Also, 2-demethylthiocolchicine (3) was oxidized to the quinone methide 7.