The stereoselectivity of antitumor active [1, 2-diamino-1-phenylpropane] dichloroplatinum (II) complexes

R Gust, M Gelbcke, B Angermaier, H Bachmann…

文献索引：Gust, Ronald; Gelbcke, Michael; Angermaier, Bernhard; Bachmann, Helmut; Krauser, Rudolf; Schoenenberger, Helmut Inorganica Chimica Acta, 1997 , vol. 264, # 1-2 p. 145 - 160

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被引用次数: 13

摘要

The syntheses of enaniomeric threo-and erythro-1, 2-diamino-1-phenylpropanes (Ph/Me) and of the racemic 1, 2-diaminophenylethane (Ph/H) are described. These diamines and related N2-methyl-and N1, N2-dimethyl-1, 2-diamino-1-phenylpropanes were transformed into dichloroplatinum (II) complexes.(Ph/H PtCl2, Ph/Me PtCl2, Ph/Me Me PtCl2, Ph/Me-Dime-PtCl2). For the 1H NMR spectroscopical determination of their optical purity ...