Total Synthesis of (+)-CC-1065 and ent-(-)-CC-1065

DL Boger, RS Coleman

文献索引：Boger, Dale L.; Coleman, Robert S. Journal of the American Chemical Society, 1988 , vol. 110, # 4 p. 1321 - 1323

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被引用次数: 56

摘要

CC-1065 (1, NSC-298223), an antitumor-antibiotic isolated from Streptomyces zelensis, initially identified by spectroscopic technique@ and confirmed in a single-crystal X-ray structure determinati~ n,~~ has been shown to possess exceptional, potent in vitro cytotoxic activity, antimicrobial activity, and confirmed, potent in vivo antitumor a~ tivity.~ In sharp contrast to the early observations made with simplified analogues of CC-1065 bearing ...