Tetrahedron

An efficient HCCP-mediated direct amination of quinazolin-4 (3H)-ones

Z Shen, X He, J Dai, W Mo, B Hu, N Sun, X Hu

文献索引：Shen, Zhenlu; He, Xiaofei; Dai, Jialiang; Mo, Weimin; Hu, Baoxiang; Sun, Nan; Hu, Xinquan Tetrahedron, 2011 , vol. 67, # 9 p. 1665 - 1672

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被引用次数: 5

摘要

An efficient direct amination of quinazolin-4 (3H)-ones has been developed. Treatment of quinazolin-4 (3H)-ones with HCCP, DIPEA, and N-contained nucleophiles in acetonitrile could be able to form the corresponding 4-aminoquinazoline derivatives. Under the optimal reaction conditions, the amination products were achieved in good yields.