European journal of medicinal chemistry

The stereoselectivity of inhibition of rat liver mitochondrial MAO-A and MAO-B by the enantiomers of 2-phenylpropylamine and their derivatives

R Bocchinfuso, JB Robinson

文献索引：Bocchinfuso, Ronald; Robinson, J. Barry European Journal of Medicinal Chemistry, 1999 , vol. 34, # 4 p. 293 - 300

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被引用次数: 2

摘要

As part of a study of the stereoselectivity of inhibition of the different forms of monoamine oxidase (MAO-A and MAO-B), the enantiomers of 2-phenylpropylamine, N-methyl-2- phenylpropylamine and N-methyl-N-propargyl-2-phenylpropylamine have been prepared. The Ki values for each enantiomer when competitively inhibiting both MAO-A and MAO-B are reported. The enantiomers of N-methyl-N-propargyl-2-phenylpropylamine were also ...