Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes

…, BS Katzenellenbogen, JA Katzenellenbogen

文献索引：Ghosh, Usha; Ganessunker, Deshanie; Sattigeri, Viswajanani J.; Carlson, Kathryn E.; Mortensen, Deborah J.; Katzenellenbogen, Benita S.; Katzenellenbogen, John A. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 4 p. 629 - 657

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被引用次数: 62

摘要

Estrogens regulate many biological functions, often acting in a tissue-selective manner. Their tissue-selective action is believed to involve differential estrogen action through the two estrogen receptor (ER) subtypes, ERα and ERβ, as well as differential interaction of the ligand–receptor complexes with promoters and coregulator proteins. In the latter case, selectivity is based on the induction of specific conformations of the ligand–ER complex, ...