Tetrahedron

A modified Robinson annulation process to α, α-disubstituted-β, γ-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal

…, CL Tai, JD Wu, JK Liang, JC Guo, NW Tseng, KS Shia

文献索引：Liu, Hsing-Jang; Ly, Tai Wei; Tai, Chia-Liang; Wu, Jen-Dar; Liang, Jinn-Kwei; Guo, Jiunn-Cheh; Tseng, Nai-Wen; Shia, Kak-Shan Tetrahedron, 2003 , vol. 59, # 8 p. 1209 - 1226

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被引用次数: 27

摘要

4-Cyano-2-cyclohexenones were found to be susceptible to reductive alkylation reactions, giving the corresponding 2, 2-disubstituted-3-cyclohexenone derivatives in a completely regioselective manner. This newly developed methodology has been successfully applied towards the total synthesis, in racemic form, of the marine natural product nanaimoal.