Tetrahedron

Etude cinétique de l'aminolyse en milieu non aqueux d'esters modèles de peptidyl-t-arn; influence d'un groupe hydroxyle voisin

M Julia, H Mestdagh

文献索引：Julia, Marc; Mestdagh, Helene Tetrahedron, 1984 , vol. 40, # 2 p. 327 - 337

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被引用次数: 2

摘要

-n-Butylaminolysis of cis 2-hydroxy-cyclopentyl benzoylglycinate (a simple model of peptidyl- t-RNA) in MeCN occurs ca 300 times faster than that of cyclopentyl benzoylglycinate. This acceleration caused by the neighbouring cis 2-hydroxy group is considerably larger than found in aqueous media for similar reactions. Trans 2-hydroxy and cis or trans 2-methoxy groups also accelerate the aminolysis, but less efficiently. Comparison between the ...