Discovery of novel thieno [2, 3-d] pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity …

T Horiuchi, Y Takeda, N Haginoya, M Miyazaki…

文献索引：Horiuchi, Takao; Takeda, Yasuyuki; Haginoya, Noriyasu; Miyazaki, Masaki; Nagata, Motoko; Kitagawa, Mayumi; Akahane, Kouichi; Uoto, Kouichi Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 991 - 1002

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被引用次数: 15

摘要

The design, synthesis, and evaluation of novel thieno [2, 3-d] pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction of a thiazole group at the hydrazone part has led to marked enhancement of chemical stability. Furthermore, by focusing on the optimization at the C-4′ position of the thiazole ring and the C-6 position ...