Heteroaromatic Tosylates as Electrophiles in Regioselective Mizoroki–Heck??Coupling Reactions with Electron??Rich Olefins

…, M Dekhane, J Grouleff, T Skrydstrup

文献索引：Gogsig, Thomas M.; Lindhardt, Anders T.; Dekhane, Mouloud; Grouleff, Julie; Skrydstrup, Troels Chemistry - A European Journal, 2009 , vol. 15, # 24 p. 5950 - 5955

全文：HTML全文

被引用次数: 41

摘要

Heteroaromatic 2-pyridyl tosylates were successfully applied as electrophiles in palladium(0)-catalyzed Mizoroki–Heck-coupling reactions to electron-rich olefins with complete α-regioselectivity. This protocol represents a general strategy for the application of pyridyl tosylates and mesylates in the Mizoroki–Heck coupling. The catalytic system also proved adaptable to changes in the heteroaromatic core as well as large-scale applications. Finally, the ...