Preparation and in vitro evaluation of monoquaternary inhibitors of brain cholinesterases

…, M Paar, J Binder, J Marek, M Pohanka…

文献索引：Jun, Daniel; Paar, Martin; Binder, Jiri; Marek, Jan; Pohanka, Miroslav; Stodulka, Petr; Kuca, Kamil Letters in Organic Chemistry, 2009 , vol. 6, # 6 p. 500 - 503

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被引用次数: 2

摘要

Acetylcholinesterase inhibitors are currently of high interest due to the many reasons. Among them, Alzheimer's disease drugs are of great interest. In this study, eleven monoquaternary pyridinium salts substituted by different groups (electron donors and electron acceptors) in position four were prepared. Then, their anticholinesterase activity was tested. As observed, their IC50s ranged from 33 μM to 3981 μM. Moreover, probability ...