The first enantioselective syntheses of axially chiral enantiomerically pure calix [4] resorcinarene derivatives

PCB Page, H Heaney, EP Sampler

文献索引：Bulman Page, Philip C.; Heaney, Harry; Sampler, Edward P. Journal of the American Chemical Society, 1999 , vol. 121, # 28 p. 6751 - 6752

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被引用次数: 41

摘要

We report here our preliminary work that is designed to address the enantioselective synthesis of axially chiral, enantiomerically pure, calix [4] resorcinarene derivatives by the enantioselective generation of diastereoisomerically pure tetrakis (benzoxazines) followed by the removal of the chiral auxiliary. The key to our strategy involves the alkylation of the four residual phenolic groups that are present in diastereoisomerically and ...