Abstract An efficient and straightforward two-step procedure for the synthesis of N-1 alkyl/aryl-substituted hydantoins was developed, starting from easily available starting materials. The procedure envisages a highly regiospecific domino condensation/aza- Michael (nucleophilic substitution)/O [RIGHTWARDS ARROW] N acyl migration between activated α, β-unsaturated carboxylic acids or α-haloaryl acetic acids, respectively, and N- ...
