Tetrahedron

Leccinine A, an endoplasmic reticulum stress-suppressive compound from the edible mushroom Leccinum extremiorientale

JH Choi, N Ozawa, Y Yamakawa, K Nagai, H Hirai…

文献索引：Choi, Jae-Hoon; Ozawa, Nobuhiko; Yamakawa, Yasuhiro; Nagai, Kaoru; Hirai, Hirofumi; Kawagishi, Hirokazu Tetrahedron, 2011 , vol. 67, # 35 p. 6649 - 6653

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被引用次数: 9

摘要

Leccinine A (1) along with a known compound (2), were isolated from the edible mushroom Leccinum extremiorientale. The structure of 1 was determined by the interpretation of spectral data. Leccinine A showed protective activity against endoplasmic reticulum stress- dependent cell death. Seven analogues (3–9) of 1 were synthesized in order to evaluate the structure–activity relationship, and the result indicated that the formamide group of 1 was ...