Organic letters

Hydrogen Bond-Stabilized Helix Formation of am-Phenylene Ethynylene Oligomer

JM Cary, JS Moore

文献索引：Cary, Jennifer M.; Moore, Jeffrey S. Organic Letters, 2002 , vol. 4, # 26 p. 4663 - 4666

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被引用次数: 72

摘要

Incorporation of a single hydrogen bonded β-turn mimic in the backbone of am-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.