Antimicrobial effects of novel siderophores linked to β-lactam antibiotics

…, D Sherman, W Schwan, MJ Hickey, P Warrener…

文献索引：Kline; Fromhold; McKennon; Cai; Treiberg; Ihle; Sherman; Schwan; Hickey; Warrener; Witte; Brody; Goltry; Barker; Anderson; Tanaka; Shawar; Nguyen; Langhorne; Bigelow; Embuscado; Naeemi Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 73 - 93

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被引用次数: 30

摘要

As a strategy to increase the penetration of antibiotic drugs through the outer membrane of Gram-negative pathogens, facilitated transport through siderophore receptors has been frequently exploited. Hydroxamic acids, catechols, or very close isosteres of catechols, which are mimics of naturally occurring siderophores, have been used successfully as covalently linked escorting moieties, but a much wider diversity of iron binding motifs ...