Synthetic Antimalarials. Some Derivatives of 8-Aminoquinoline1

NL Drake, HD Anspon, JD Draper…

文献索引：Drake et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1542

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摘要

Plasmochin (pamaquine), 6-(4-diethylamino-l-methylbutylamino)-6-methoxyquinoline, and its derivatives have been the subject of an immense amount of research because of the reported curative action of Plasmochin on vivax malaria2 when the drug is administered with quinine at approximately the maximum tolerated dosage level. The high toxicity of Plasmochin which is reputedly greater for non-Caucasian races, has prompted an ...