Tetrahedron

A Pd [0]-catalyzed Ullmann cross-coupling/reductive cyclization approach to C-3 mono-alkylated oxindoles and related compounds

…, MT Jones, DTJ Loong, DW Lupton, DM Pinkerton…

文献索引：Banwell, Martin G.; Jones, Matthew T.; Loong, David T.J.; Lupton, David W.; Pinkerton, David M.; Ray, Jayanta K.; Willis, Anthony C. Tetrahedron, 2010 , vol. 66, # 47 p. 9252 - 9262

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被引用次数: 20

摘要

The Pd [0]-catalyzed Ullmann cross-coupling of o-nitrohaloarenes 1a–e with the brominated heterocycles 2a–f delivers the expected products 3a–j in good to excellent yields. The reductive cyclization of such products, as well as N-acyl derivatives 3k, l, and m, has been investigated and provided the C-3 mono-substituted oxindoles 5a–d, f, g, k, and m, the direct reduction products 4i and j or indole 5l.