Synthesis and structural studies of certain novel imidazo [1, 2-b] pyrazole nucleosides

SG Wood, NK Dalley, RD George…

文献索引：Wood; Dalley; George; et al. Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3534 - 3540

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被引用次数: 16

摘要

The first chemical syntheses of imidazo [l, 2-b] pyrazole-7-carbonitrile (3), the corresponding ribonucleosides (10 and 16), and certain related derivatives of a new class of purine analogues containing a bridgehead nitrogen atom are described. Condensation of 2- hydrazinoacetaldehyde diethyl acetal with (ethoxymethy1ene) malononitrile and subsequent ring closure gave 3. Direct glycosylation of the Me3Si derivative of 3 with ...