A new procedure for the cyclization of 2??indole??and 3??indolecarbohydrazones to 5H??pyridazino [4, 5??b] indole derivatives

…, JA Palop, MT Martinez, EF Alvarez

文献索引：Vega, A. Monge; Palop, J. A.; Martinez, M. T.; Alvarez, E. Fernandez Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 249 - 256

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被引用次数: 3

摘要

Abstract A new procedure for the cyclization of 2-indolecarbohydrazones (5) to 1, 2, 3, 4- tetrahydro-4-oxo-5H-pyridazino [4, 5-b] indoles (6) and for the cyclization of 3- indolecarbohydrazones (7) to 1-oxo-1, 2, 3, 4-tetrahydro-5H-pyridazino [4, 5-b] indoles (8 and 9) is described. The hydrazones (5 or 7) were treated with an acyl halide (acetyl or benzoyl chlorides) and triethylamine in ethyl acetate of chloroform as solvents to give the ...