Synthesis and anticancer activity of nitrosourea derivatives of phensuximide

AM Crider, TM Kolczynski, KM Yates

文献索引：Crider, A. Michael; Kolczynski, Thomas M.; Yates, Kathleen M. Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 324 - 326

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被引用次数: 34

摘要

The difficulty in the treatment of primary tumors of the central nervous system (CNS) and solid tumors metastasizing to the CNS from a variety of other primary sites, such as the breast and lungs, has been discussed.'-4 However, some degree of success has been achieved with the development of new antitumor drugs with CNS activity. Several nitrosourea derivatives have been reported to exhibit activity against murine leukemia ...