The role of a quinone methide in the sequence specific alkylation of DNA

M Chatterjee, SE Rokita

文献索引：Chatterjee, Moneesh; Rokita, Steven E. Journal of the American Chemical Society, 1994 , vol. 116, # 5 p. 1690 - 1697

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被引用次数: 69

摘要

Abstract: Oligonucleotide-naphthoquinone conjugates were prepared and examined for use as inducible, site-directed alkylating agents of DNA. Reaction was found to be sequence specific and under control of either biomimetic reduction or near-UV irradiation. Both ...