Hypoxia-selective antitumor agents. 8. Bis (nitroimidazolyl) alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitizers

…, WR Wilson, JW Moselen, BD Palmer…

文献索引：Hay; Wilson; Moselen; Palmer; Denny Journal of Medicinal Chemistry, 1994 , vol. 37, # 3 p. 381 - 391

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被引用次数: 69

摘要

A series of novel bis (nitroimidazoly1) alkanecarboxamides has been prepared and evaluated for hypoxia-selective cytotoxicity and hypoxic cell radiosensitisation in vitro and in vivo. The compounds were prepared by direct coupling of preformed side chain acid and amine components, using diethyl phosphorocyanidate at room temperature. Although designed to be bis-bioreductive prodrugs of DNA cross-linking agents, none of the ...